Combination of Biochanin A and Temozolomide Impairs Tumor Growth by Modulating Cell Metabolism in Glioblastoma Multiforme
نویسندگان
چکیده
منابع مشابه
In Vitro Radiosensitizing Effects of Temozolomide on U87MG Cell Lines of Human Glioblastoma Multiforme
Background: Glioma is the most common primary brain tumor with poor prognosis. Temozolomide (TMZ) has been used with irradiation (IR) to treat gliomas. The aim of the present study was to evaluate the cytotoxic and radiosensitizing effect of TMZ when combined with high-dose and high-dose rate of gamma irradiation in vitro.Methods: Two ‘U87MG’ cell lines and skin fibroblast were cultured and ass...
متن کاملin vitro radiosensitizing effects of temozolomide on u87mg cell lines of human glioblastoma multiforme
background: glioma is the most common primary brain tumor with poor prognosis. temozolomide (tmz) has been used with irradiation (ir) to treat gliomas. the aim of the present study was to evaluate the cytotoxic and radiosensitizing effect of tmz when combined with high-dose and high-dose rate of gamma irradiation in vitro. methods: two ‘u87mg’ cell lines and skin fibroblast were cultured and as...
متن کاملGlioblastoma Multiforme in Children, A Case-Report
ABSTRACT: Glioblastoma multiforme is the most malignant primary brain tumor .It usually occurs in the 5th and 6th decades of life and is rare in childern. In this paper a case of glioblastoma multiforme is reported in a ten year - old child who presented with two week's history of headache with no neurological defect.C.T scan revealed å right frontal mass with massive surrounding oedema. He w...
متن کاملTemozolomide and thalidomide in the treatment of glioblastoma multiforme.
OBJECTIVE The aim of this study was to assess efficacy and toxicity of temozolomide given alone or in combination with thalidomide, an anti-angiogenetic drug, in patients with newly diagnosed glioblastoma multiforme (GBM). PATIENTS AND METHODS 46 patients with histologically proven GBM were eligible for inclusion. Twenty-three patients (15 males and 8 females) received temozolomide on a conve...
متن کاملBevacizumab in combination with radiotherapy and temozolomide for patients with newly diagnosed glioblastoma multiforme.
BACKGROUND Patients with a newly diagnosed glioblastoma multiforme (GBM) have a high risk of recurrent disease with a dismal outcome despite intensive treatment of sequential surgery and chemoradiotherapy with temozolomide (TMZ), followed by TMZ as a single agent. Bevacizumab (BV) may increase response rates to chemotherapy in the recurrent treatment setting of GBM. We hypothesized that a neoad...
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ژورنال
عنوان ژورنال: Anticancer Research
سال: 2018
ISSN: 0250-7005,1791-7530
DOI: 10.21873/anticanres.13079